Do polynucleotide injections improve skin quality? What nine studies found

What question did the researchers ask?

The review examined human studies of injectable polynucleotides in aesthetic medicine published between 2010 and early 2024. It compared treatment areas, techniques, outcomes and study quality.

What did they actually find?

Several studies reported improvements in wrinkles, texture and elasticity, with moderate-to-high satisfaction and mainly mild, temporary side effects.

What should you keep in mind?

The nine studies were rated low or moderate quality and used varied protocols. The authors found no clear consensus on best technique, area or course, so treatment remains a product-specific, evidence-limited conversation.

What does this mean for a Highfield consultation?

Published evidence is limited and there is no firm consensus on an ideal protocol. We consider that finding alongside independent guidance, your medical history, examination and priorities. It can support a better-informed decision, but it cannot promise a personal result or decide whether treatment is suitable.