Does topical tretinoin improve photoageing? A review of the evidence

What question did the researchers ask?

The review examined randomised trials of topical tretinoin for photoageing. Concentrations and treatment durations varied widely, from three months to two years.

What did they actually find?

The included trials consistently reported improvements in visible photoageing measures such as fine wrinkling, mottled pigmentation, sallowness and sun spots.

What should you keep in mind?

This is ingredient-specific evidence for prescription tretinoin, not proof that every “medical-grade” product is superior. Formulations and outcomes differed, and suitability depends on irritation risk, pregnancy status and the rest of the routine.

What does this mean for a Highfield consultation?

Evidence is ingredient-specific; a suitable routine depends on diagnosis, tolerance, pregnancy status and other treatments. We consider that finding alongside independent guidance, your medical history, examination and priorities. It can support a better-informed decision, but it cannot promise a personal result or decide whether treatment is suitable.